U.S. Route 69 (US-69) is a major north-south U.S. Highway that runs from Port Arthur, Texas to Albert Lea, Minnesota.

The highway crosses US-166 west of Treece before K-7 leaves the concurrency with the intersection of US-160 in Columbus, of which U.S. 160 begins another overlap with U.S. 69.

Just after US-69 meets the eastern terminus with K-47 in Franklin, the route reverts back to a 2-lane highway before entering the town of Arma.

US-69 meets with K-7 for a second time as a partial interchange and the two routes continue north to Fort Scott.

[1] It replaced the Argentine Boulevard bridge over the river behind the modern-day BNSF railroad yard.

[2] Upon completion of the bridge, US-69 was rerouted onto the expressway from Southwest Boulevard (the section of which has since been renamed to Merriam Drive).

[3] In early April 2020, a $21.8 million construction project to finish a four-lane expressway from Pittsburg to Kansas City began.

[4] As Overland Park has grown in recent years, US-69 south of 103rd Street has become the busiest four-lane highway in Kansas.

is a special route of U.S. Highway 69, traveling 20.3 miles (32.7 km) between junctions east of Commerce, Oklahoma and north of Crestline, Kansas.

US-69 Alt., cosigned with Historic Route 66, splits from mainline US 69 south of Picher and west of Quapaw.