U.S. Highway 6 (US-6) in the U.S. state of Nebraska is a United States Numbered Highway which goes from the Colorado border west of Imperial in the west to the Iowa border in the east at Omaha.

Also, from Milford east to the Iowa border, the highway is closely paralleled by Interstate 80 (I-80).

Large portions of the route parallel the Chicago, Burlington and Quincy Railroad.

US-6 enters Nebraska from Colorado west of Imperial on a short southeasterly segment.

The two routes are paired together until they separate at the Enders Reservoir State Recreation Area.

US-6/US-34 continue together in a northeasterly direction through Cambridge, then turns due east and meets US-283 in Arapahoe.

[1][2] At this point, US-6 goes onto the freeway, the West Dodge Expressway, and turns due east to go toward Downtown Omaha.

Between 120th and 108th streets, US-6 is an elevated freeway with separate viaducts for eastbound and westbound traffic.

The Nebraska Department of Roads is planning a total rebuild and partial realignment/rerouting of US-6 from its current path along Sun Valley Boulevard in Lincoln.