U.S. Route 6 (US 6) is a part of the United States Numbered Highway System that runs from Bishop, California, to Provincetown, Massachusetts.

The highway travels through largely farm and field country until it reaches Sandusky.

The highway goes east from the border, passing through the small town of Edgerton, where it has a brief concurrency with State Route 49 (SR 49).

Continuing east through farm country, US 6 passes through Ridgeville Corners, until reaching Napoleon in Henry County, where it intersects US 24, starting a 4.6-mile-long (7.4 km) concurrency.

US 6 passes south of the college town of Bowling Green 15 miles (24 km) east of McClure, intersecting with Interstate 75 (I-75).

In Sandusky County, US 6 passes through the small towns of Rollersville and Helena before reaching the city of Fremont.

US 6, along with US 20, splits from SR 2 just before it crosses the Cuyahoga River on the Main Avenue Bridge.

At the east end of the bridge, following Superior Avenue, US 6 passes through Public Square.

[7] After splitting from US 20, US 6 runs concurrent with SR 84 for 2.1 miles (3.4 km) before entering Lake County.

In Chardon, US 6 turns northeast to serve Hambden and Montville townships before crossing into Ashtabula County.

In Ashtabula County, US 6 travels straight east through the townships of Hartsgrove, Rome, New Lyme, and Cherry Valley, as well as the village of Andover before turning north with SR 7.

Major William Anderson Jr. took notice of this and proposed the idea of redesignating the highway to honor Union forces during the Civil War.

Each state had approved the renaming by 1953, and it was in that year that US 6 was designated as the Grand Army of the Republic Highway along its entire length.