U.S. Route 36 (US 36) is an east–west United States Numbered Highway that travels approximately 1,414 miles (2,276 km) from Rocky Mountain National Park, Colorado to Uhrichsville, Ohio.

The highway's western terminus is at Deer Ridge Junction, an intersection in Rocky Mountain National Park, Colorado, where it meets US 34.

Between Denver and Byers, US 36 exists in unsigned overlaps with I-270 and I-70, while some parts of its original route are signed separately as Colorado State Highway 36 (SH 36).

Except for wider sections in towns and passing lanes on hills, US-36 through Kansas is mostly a two-lane surface road.

US 36 across Missouri is a four-lane expressway with some freeway sections, passing through or near St. Joseph, Cameron, Chillicothe, Brookfield, Macon, Monroe City and Hannibal.

Just prior to crossing the Mark Twain Memorial Bridge, US 36 also encounters the western terminus of I-72 and all three routes run concurrently into Illinois.

The route then travels mostly in a straight line, passing through Sulphur Springs, Losantville, Modoc, and Lynn before entering Ohio.

The Birthplace of Rutherford B. Hayes, 19th President of the United States, 17 E. William St., Delaware, is on the north side of US 36, approximately 0.2 miles (0.32 km) west of the US 23 overpass.