It also serves as a route for vehicles carrying hazardous cargo that are prohibited from using the larger George Wallace Tunnel on Interstate 10.

16, North Broad Street carries all four routes northwest until passing the intersection of Congress Street, then makes a sharp curve to the northeast passing S D Bishop State Junior College and Bishop State Community College.

North of Dr. Martin Luther King Jr. Avenue (formerly Glidden Place), the routes make an east-northeasterly turn onto Beauregard Street.

At the intersection with North Water Street, all routes make a left turn at the southern terminus of I-165.

New Bay Bridge Road passes through historic Africatown, where it has an interchange with the southern terminus of US 43, which is also where AL 13 leaves, then drops the "new" from the street name, encroaching on more industrial surroundings as it encounters interchanges with Paper Mill Road and Clint Street before crossing the Cochrane–Africatown USA Bridge onto Blakely Island where the routes curve straight south onto the Old Spanish Trail.

U.S. Truck Route 98 ends at the eastern portal of the Bankhead Tunnel just north of Exit 27 on I-10, where US 90 and 98 continue onto another concurrency, this time in the same direction over Battleship Parkway.

It currently serves as a business route along the coast of Panama City between St. Andrews and Parker.

Although a significant portion of the truck route exists within the city limits, it still avoids historic downtown Brooksville by moving to the south and the west.

Here, State Road 700 leaves the truck route, and heads north along US 41 (SR 45) until branching off to Ponce De Leon Boulevard to rejoin US 98.

Meanwhile, SR 50/Truck US 98 passes a branch of the Brooksville Post Office, and makes a northbound curve at Horse Lake Drive, then at the Hernando County Sheriff's Office before meeting West Jefferson Road.

While SR 50 takes its sharp left turn toward Weeki Wachee, and SR 50A begins eastbound into downtown Brooksville, Truck Route US 98 continues north along County Road 485, also known as Cobb Road.

U.S. Highway 98 Alternate was the original segment of US 98 in Panama City Beach, Florida until U.S.

It also includes a pair of wye intersections with both legs of the southern terminus of State Road 79.

The road doesn't begin to move away from the beach until east of Dement Circle, when it turns northeast, and then intersects with South Thomas Drive, and then the western terminus of County Road 392 and eastern terminus of CR 392A.

The route ran along parts of Broadway and Main Street in Downtown Bartow.