2Q3E, 2QG4, 3ITK, 3KHU, 3PRJ, 3PTZ, 3TDK, 3TF5, 4EDF, 4QEJ, 4RJT735822235ENSG00000109814ENSMUSG00000029201O60701O70475NM_001184700NM_001184701NM_003359NM_009466NP_001171629NP_001171630NP_003350NP_033492UDP-glucose 6-dehydrogenase is a cytosolic enzyme that in humans is encoded by the UGDH gene.

These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis.

The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.

Loss of UGDH has recently been implicated in epileptic encephalopathy in humans[8] This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.

Other names in common use include: In enzymology, a UDP-glucose 6-dehydrogenase (EC 1.1.1.22) is an enzyme that catalyzes the chemical reaction The 3 substrates of this enzyme are UDP-glucose, NAD+, and H2O, whereas its 3 products are UDP-glucuronate, NADH, and H+ References:[9][10][11][12]