UFC 259: Błachowicz vs. Adesanya was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on March 6, 2021 at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States.

[10] The pairing was initially scheduled for UFC 256, but Nunes pulled out due to an undisclosed injury and the bout was postponed.

[11] A UFC Bantamweight Championship bout between current champion Petr Yan and Aljamain Sterling completed the triad of title fights.

[17] They were previously scheduled to meet in April 2016 at UFC on Fox: Teixeira vs. Evans, but the bout was scrapped after Makhachev failed an out-of-competition drug screening, testing positive for the banned anti-ischemic meldonium.

His bout proceeded at a catchweight and he was fined a percentage of his individual purse, which went to his opponent, former flyweight title challenger Joseph Benavidez.