[2][3] A UFC Heavyweight Championship rematch bout between current two-time champion Stipe Miocic and Francis Ngannou headlined this event.

[4] The pairing met previously at UFC 220 on January 20, 2018, where Miocic won via unanimous decision and broke the record for most consecutive title defenses for the division with his third.

[5] A UFC Featherweight Championship bout between current champion Alexander Volkanovski and former title challenger Brian Ortega would have served as the co-main event.

[16] A women's strawweight bout between Randa Markos and promotional newcomer Luana Pinheiro was expected to take place at the event.

[22] A light heavyweight bout between Alonzo Menifield and William Knight was originally expected to take place at UFC Fight Night: Rozenstruik vs.

[24] The bout was then rescheduled for this event, but this time Knight was removed due to COVID-19 protocols and was replaced by promotional newcomer Fabio Cherant.