UFC 261: Usman vs. Masvidal 2 was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on April 24, 2021 at VyStar Veterans Memorial Arena in Jacksonville, Florida, United States.

However, negotiations with the Singaporean government fizzled amongst COVID-19 protocols and the promotion initially turned to their home base of Las Vegas.

[9] They met previously in September 2010 at a Ring of Combat event for the organization's middleweight title, with Weidman winning via TKO.

[13] However, Walker pulled out due to an injury and was replaced by former UFC Light Heavyweight Championship challenger Anthony Smith.

[17] However, Striegl was removed from the bout on March 24 due to undisclosed reasons and replaced by Jamey Simmons.