UFC 263: Adesanya vs. Vettori 2 was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on June 12, 2021, at the Gila River Arena in Glendale, Arizona, United States.

[6] A UFC Flyweight Championship rematch between champion Deiveson Figueiredo and former title challenger Brandon Moreno took place as the co-main event.

[8] The pairing was previously scheduled to take place at UFC on ESPN: Brunson vs. Holland, but Hill withdrew from that event on March 10 after testing positive for COVID-19.

[11] Despite the different date, the pairing retained its original status, marking the first time in UFC history that a non-title bout other than the main event was scheduled for five rounds.

In turn, Eubanks was removed from the card and will face Priscila Cachoeira six weeks later at UFC Fight Night: Sandhagen vs. Dillashaw instead.

[21] ¹ Although not recognized on the official pay sheet, Steven Peterson was fined 20 percent of his purse ($9,200) for failing to make the required weight for his fight with Chase Hooper.