UFC 265: Lewis vs. Gane was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on August 7, 2021, at the Toyota Center in Houston, Texas, United States.

[2] An interim UFC Heavyweight Championship bout between former title challenger Derrick Lewis and Ciryl Gane headlined the event.

[5] Johnny Muñoz Jr. and Jamey Simmons were expected to meet in a bantamweight bout at UFC 261, but the latter pulled out due to undisclosed reasons.

[11] The rematch was originally scheduled to take place in December 2020 at UFC 256, but Hill tested positive for COVID-19 during the week leading up to the event and was removed from the bout.

[13] The pair was scheduled to meet at UFC on ESPN: Makhachev vs. Moisés, but it was removed just hours before the show due to COVID-19 protocol issues stemming from dos Santos' camp.