[3] A UFC Welterweight Championship rematch between the current champion Kamaru Usman (also The Ultimate Fighter: American Top Team vs. Blackzilians welterweight winner) and former interim champion Colby Covington headlined the event.

[4] Serving as the event headliner, they previously met at UFC 245 in December 2019, where Usman defended his title via fifth-round technical knockout.

[13] Phil Hawes and Chris Curtis were expected to meet in a middleweight bout at UFC Fight Night: Dern vs. Rodriguez a month earlier, but due to Curtis being tapped as a replacement just a day before that event, Hawes declined the matchup.

[7] A light heavyweight fight between Aleksa Camur and John Allan was scheduled for the event.

[19] However, Camur pulled out of the bout citing an undisclosed injury and was replaced by Dustin Jacoby.