[3] They were initially scheduled to serve as the headliner for UFC on ESPN: Smith vs. Clark in November, but the contest was scrapped due to Blaydes testing positive for COVID-19.

[10] The pairing was previously scheduled to take place in December of 2020 at UFC Fight Night: Thompson vs. Neal, but it was scrapped in the days leading up to that event after Zahabi tested positive for COVID-19.

[11] A middleweight bout between Phil Hawes and Nassourdine Imavov originally expected to take place at UFC on ABC: Holloway vs. Kattar, but was scrapped due to undisclosed reasons just a few hours before the event.

[19] At the weigh-ins, Ketlen Vieira, Jared Gordon, Drako Rodriguez and Rafael Alves missed weight for their respective bouts.

[22] However, the bout was canceled moments before it was expected to begin as Emmers suffered back spasms backstage rendering him unable to compete.