[2][3] A welterweight bout between Leon Edwards and Khamzat Chimaev was expected to serve as the main event.

[4] The pairing has been scheduled as headliner and cancelled on two previous occasions due to COVID-19 related issues affecting both fighters.

[10] However, on January 7, news surfaced that Rivera was arrested for two counts of attempted murder in Palm Beach County, Florida after he allegedly stabbed his two sisters.

[16] However, they were moved to headline UFC Fight Night: Rozenstruik vs. Gane after the original main event between former UFC Light Heavyweight Championship challenger Dominick Reyes and former Rizin Light Heavyweight Champion Jiří Procházka was cancelled due to undisclosed reasons.

Team Faber lightweight winner Ryan Hall was expected to face Dan Ige in a featherweight bout at the event.

[25] Misha Cirkunov was expected to face Ryan Spann in a light heavyweight bout at UFC Fight Night: Thompson vs. Neal.

[30] The two met before at The Ultimate Fighter: Redemption Finale in July 2017, with Hill winning via unanimous decision.

[32] A featherweight bout between Ricardo Ramos and Zubaira Tukhugov was expected to take place during the preliminary portion of the event.