On July 27, 1907, the general municipal hospitals and subsequently the Düsseldorf Academy for Practical Medicine were officially opened.

On the site were the clinics for surgery, internal medicine pediatrics, with Arthur Schloßmann as head physician, gynecology and obstetrics with Hugo Sellheim as head physician, infectious diseases with an attached institute for experimental therapy, skin and venereal diseases, ear, nose and throat medicine, ophthalmology and pathology under the direction of Lubarsch.

The University of Düsseldorf has now moved into the first new buildings on the campus south of the clinic site.

The facilities, which were primarily used for clinical care and research, remained on the hospital grounds.

The modernization process included the new data center at the site of the old boiler house.

[2] As part of the "Giga for Health" innovation project, Düsseldorf's University Hospital will become the first 5G medical campus in Europe.

[4] The German Cancer Aid included the university hospital in its list of top oncology centers for the first time in 2013.

This is associated with funding from the University Tumor Center Düsseldorf (UTZ) totaling three million euros for three years.