It is a major transfer point between Metro Rail and many city and suburban bus routes and offers a unique "Kiss and Ride" facility on the top level, above the mezzanine.

[2] University station serves UB South and is a transfer point for buses to the north and northeast suburbs of the city and is also one of four stations that offers an off-road bus loop, requiring passengers to board/debark using curbside stops (the other three being LaSalle, Delavan/Canisius College and Utica) and is served by 11 bus routes: In 1979, an art selection committee was created, composed of NFTA commissioners and Buffalo area art experts, that would judge the artwork that would be displayed in and on the properties of eight stations on the Metro Rail line.

The work from Stephen Antonakos is called "Neon for South Campus Station" and is an "abstract form of neon tubing, creating large, incomplete circles and incomplete squares, mounted on the interior ceiling of the mezzanine level of the station."

[5] Harvey Breverman's work is "a large triptych on a semi-circular wall at the foot of the escalators at the trainroom level."

[5] Beverly Pepper's work is a sculpture of steel and grass located in the bus loop entitled Vertical Presence-Grass Dunes.