The station has been referenced by rapper Westside Gunn numerous times.

Located on a triangular tract of land bounded by Main Street to the east, Amherst Street to the north and Parker Avenue to the west, Amherst Street is one of four stations that does not offer an off-road bus loop, requiring passengers to board/debark using curbside stops (the other three being Humboldt-Hospital, Summer-Best and Allen/Medical Campus).

Route 23 buses heading toward Bailey/Abbott Loop and route 32 buses heading towards Black Rock/Riverside Transit Hub do not board at the curb on the same side as the station, which is served by three bus routes: In 1979, an art selection committee was created, composed of NFTA commissioners and Buffalo area art experts, that would judge the artwork that would be displayed in and on the properties of eight stations on the Metro Rail line.

Out of the 70 proposals submitted, 22 were chosen and are currently positioned inside and outside of the eight underground stations.

[3] Amherst station is home of three pieces of work, from Aleksandra Kasuba (New York City), Ray Hassard (Buffalo) and Robert Lawrance Lobe (New York City).