Upper Esk is a rural locality in the local government areas (LGA) of Break O'Day and Dorset in the North-east LGA region of Tasmania.

The locality is about 68 kilometres (42 mi) southeast of the town of Scottsdale.

The 2016 census recorded a population of 26 for the state suburb of Upper Esk.

[3] The South Esk River rises in the north of the locality and flows through to the east.

Route C423 (Mathinna Plains Road) runs along part of the eastern boundary.