Uroporphyrinogen-III C-methyltransferase

Uroporphyrinogen-III C-methyltransferase (EC 2.1.1.107), uroporphyrinogen methyltransferase, uroporphyrinogen-III methyltransferase, adenosylmethionine-uroporphyrinogen III methyltransferase, S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase, uroporphyrinogen-III methylase, SirA, CysG, CobA, uroporphyrin-III C-methyltransferase, S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase.

[1][2][3] This enzyme catalyses the following chemical reaction Uroporphyrinogen-III C-methyltransferase catalyses two methylation reactions.

The first reaction converts uroporphyrinogen III into precorrin-1.

The second converts precorrin-1 into precorrin-2.

These reactions are part of the biosynthetic pathway to cobalamin (vitamin B12) in both anaerobic and aerobic bacteria.

uroporphyrinogen III substrate of the enzyme
precorrin-2 product of the enzyme