Uruguay is scheduled to compete at the 2023 Pan American Games in Santiago, Chile from October 20 to November 5, 2023.

On 9 October 2023, the Uruguayan Olympic Committee officially named the team of 179 athletes (103 men and 76 women) competing in twenty nine sports.

[1] Footballer Rodrigo Chagas and boxer Camila Piñeiro were the country's flagbearers during the opening ceremony.

[2][3] Meanwhile, sailor Fernando Becerra and basque pelota athlete Leonella Acosta were the country's flagbearers during the closing ceremony.

Uruguay qualified a team of seven athletes (three men and four women) through the 2023 Pan American Basque Pelota Tournament.

[11] Uruguay qualified a men's team of 18 athletes by virtue of its campaign in the 2023 South American U-20 Championship.

[15] Uruguay qualified a women's team (of 14 athletes) by winning the Last chance qualification tournament.

[22][23] Uruguay qualified a men's team (of 12 athletes) after finishing third at the 2022 South American Games.