Since the nation's official debut in 1920, Uruguayan athletes have appeared in every edition of the Summer Olympic Games, except for Moscow 1980 as part of the United States-led boycott.

Alain Mikael Aprahamian (men's half-middleweight, 81 kg) got qualified via continental quota based on Olympic point rankings.

Uruguayan rowers qualified one boats in the men's single sculls for the Games, through the 2024 Americas Qualification Regatta in Rio de Janeiro, Brazil.

Uruguayan sailors qualified one boat in each of the following classes through the 2023 Pan American Games in Santiago, Chile, and 2024 ILCA 6 World Championships in Mar del Plata, Argentina.

María Sara Grippoli secured her spot through the 2024 Pan American Qualification Tournament, in Santo Domingo, Dominican Republic.