[5] On 20 February 2007, Barry Minkow, founder of the Fraud Discovery Institute, distributed a 500-page report to officials at the U.S. Securities and Exchange Commission (SEC), the Federal Bureau of Investigation (FBI), and the Internal Revenue Service (IRS) accusing Usana of operating an illegal pyramid scheme.

[10][11] The SEC conducted an investigation of Usana's business practices in March 2007 and found nothing incriminating, concluding its inquiry with no enforcement action recommended.

[13] In April 2007, a class action lawsuit was filed that alleged Usana common stock had artificially inflated prices.

[14][15] In August 2007, Usana was notified by the Securities and Exchange Commission (SEC) that its shares were subject to delisting from the NASDAQ due to its Form 10-Q, and was determined to be in compliance that October.

[16][17] In January 2008, a shareholder suit was filed with allegations that Usana had misled investors about the sustainability of its growth and business model.

In 2015, Usana announced that the chief executive officer role would be divided between Wentz and Kevin Guest with the former taking global operations and for the latter, field development and sales.

The firm's 2010 income disclosure statement defines "associates" as those who are actively building a business, acting as wholesale buyers, or are new distributors.

The program permits selected participants to enter into an agreement with company stipulating that, should an athlete enrolled in the program test positive for a banned substance (included in World Anti-Doping Agency regulations) as a result of taking Usana products, the company will compensate the athlete up to two times his or her current annual earnings up to $1 million USD.

[65][66] As part of the agreement in 2011, Usana donated $1 to Children's Hunger Fund for every ace scored at a WTA tournament beginning at Wimbledon and continuing through the end of the season.

[75] As of 2019, its products are marketed in the United States, Canada, Australia, New Zealand, Hong Kong, Japan, Taiwan, South Korea, Singapore, Mexico, Malaysia, the Netherlands, the United Kingdom, Caribbean, Puerto Rico, Philippines, France, China, Spain, Italy, Germany, Romania, Denmark, Colombia and Indonesia.

[77] In 2007, a Forbes article quoted industry experts and government officials who had raised questions about the cost of Usana's supplements as well as its business practices.

[78][79] Radio-Canada later aired an investigative report that examined the company's products, pricing and "misleading income claims" made to potential associates concerning revenue.

It included hidden camera filming of recruitment and other sessions, which found one group of associates appeared to violate the company's policies and distributor agreements.

This contrasted the Canadian legal requirements for multi-level marketing companies to provide clear, frequent and complete information about the revenue of the typical participant.

Cloud also experienced a placebo response where that act of taking the supplements made him feel more vigorous despite no physiological reasons being present.