The highway begins in Loa and proceeds north towards Fremont and across Fishlake National Forest.

The portion across Fishlake National Forest is frequently closed during winter weather.

While in the national forest the highway passes by landmarks such as Foy Bench and The Frying Pan.

[5] State Route 250 was created in 1953 as a connection from SR-24 between Loa and Lyman north to the 90° turn in SR-72,[6] but was given back to the county in 1969.

Since there was no interchange at Fremont Junction, SR-72 was extended east about two miles (3 km) to the point where I-70 left the SR-10 alignment to cross the San Rafael Swell.