1FLT, 1QSV, 1QSZ, 1QTY, 1RV6, 2XAC, 3HNG, 4CKV, 4CL7, 5EX3232114254ENSG00000102755ENSMUSG00000029648P17948P35969NM_001159920NM_001160030NM_001160031NM_002019NM_010228NM_001363135NP_001153392NP_001153502NP_001153503NP_002010NP_034358NP_001350064Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.

It encodes a receptor tyrosine kinase which is activated by VEGF-A, VEGF-B, and placental growth factor.

The sequence structure of the FLT1 gene resembles that of the FMS (now CSF1R) gene; hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.

[7] Functional genetic variation in FLT1 (rs9582036) has been found to affect non-small cell lung cancer survival.

[8] FLT1 has been shown to interact with PLCG1[9] and vascular endothelial growth factor B (VEGF-B).