6411574048ENSG00000107738ENSMUSG00000020101Q9H7M9Q9D659NM_022153NM_001159572NM_028732NP_071436NP_001153044NP_083008V-domain Ig suppressor of T cell activation (VISTA) is a type I transmembrane protein that functions as an immune checkpoint and is encoded by the VSIR gene.

[8][5] VISTA is part of the B7 family, is primarily expressed in white blood cells and its transcription is partially controlled by p53.

[5][8] Similarly, VISTA and TIM-3 may co-exist on macrophages infiltrating different human and mouse tumours where they can co-regulate immunotherapy resistance.

[16] Preliminary results of the phase I clinical trials show good safety tolerance and anti-cancer activity in patients with advanced tumours.

[18] Another ongoing clinical trial involves a small molecule that antagonizes the programmed death-ligands 1 and 2 (PD-L1 and PD-L2), and VISTA pathways in patients with advanced solid tumors or lymphomas.