[5] The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21[6][7] throughout Madera County, Fresno, and California.

[9][10][11] Valley Children's also features the largest ACS verified Level 2 Pediatric Trauma Center in the region, the only Level IV NICU in the Central Valley, and the only provider of pediatric extracorporeal life support (ECLS) for their service area.

[19] In 1998 they moved to a 50 acre site in Madera County, on the other side of the San Joaquin River from Fresno.

[21] In June 2015, Valley Children's Healthcare announced a decision to separate from UCSF Fresno and instead partner with Stanford University for medical education and research.

[31][32] In addition, most of its legally mandated direct community investment was passed to its associated medical group, which was criticized by hospital finance experts as "gaming the system" and unusual.

[44] As of 2021-22, Valley Children's Hospital has placed nationally in 7 ranked pediatric specialties on U.S. News & World Report.

Valley Children's Hospital serves as a training site for a variety of pediatric health professionals.