In addition to Keosauqua, it also serves Birmingham, Bonaparte, Cantril, Farmington, Hillsboro, Milton, and Stockport.

It also serves two census-designated places in unincorporated Van Buren County: Douds and Leando.

[4] The predecessor districts had begun a grade-sharing arrangement in which Harmony-zoned students attended Van Buren schools for grades 7–12 in 2016.

[6] In January 2018, the administrations of the Van Buren and Harmony districts began to consider merging.

[8] There was a single superintendent and school board for both areas beginning on July 1, 2019.