VT 25 begins at the New Hampshire state line just south of the village of Bradford.

The road continues across the state line at the Connecticut River as New Hampshire Route 25.

Approximately 0.5 miles (0.8 km) west of the state line, VT 25 intersects with U.S. Route 5, which leads to the town center.

It travels through mainly rural areas, passing through the small settlements of Bradford Center and East Corinth.

VT 25 continues approximately 0.3 miles (0.48 km) after crossing into the town of Orange, where it ends at an intersection with U.S. Route 302.