Prince Giuseppe Beretta, Duke of Simari and Marquis of Mesagne, commissioned designs for a new building from the architect Ferdinando Fuga, and in 1762 the villa was completed.

In 1768, the prince gave a sumptuous party in honour of the King Ferdinand IV of Naples and his new wife, the Habsburg Maria Carolina of Austria, just arrived from Vienna.

From 1879 and 1885 Villa Favorita hosted the exiled Isma'il Pasha, former Khedive of Egypt who had presided over the inauguration of Suez Canal.

The interiors were decorated and frescoed by Andrea Giusti, Domenico Ascione and Filippo De Pascale.

The interiors were highly decorated in a florid Rococo style, with stucco, woodwork, mirrors and glasswork.