The palace was built circa 1757,[4] by Francesco Preziosi,[5] with baroque architecture that gave a sense of pride and power to noble people at the time.

The first ambitious owner became bankrupt[4] with the expenses of the palace, to make it an outstanding and incomparable building, and because of this he was pressured to sell his possession by the Order of St. John to pay his accumulated debts.

[11] Former Prime Minister of Malta Sir Ugo Pasquale Mifsud and his wife (ne Francia) lived at the palace between September 1924 and August 1927, and between June 1932 and November 1933.

As per agreement between the State of Malta and the Local Church, the property passed to the government, even though the Francia kept using it.

[11] A million euro have been invested for the preservation and restoration of Villa Francia by the government partially from EU funds.

[14] The palace today serves as the residence of the Prime Minister of Malta where general activities take place.

The palace became more notable when Monsignor Charles Scicluna was elected as Bishop of Malta and he was welcomed to the building by Prime Minister Joseph Muscat.

[15] The restoration of the entire estate is aimed to bring about regional development by opening it for the public and become a tourist attraction.

[6] The Malta Environment and Planning Authority (MEPA) has scheduled Villa Francia as grade 1 national monument.