Tututepec served as a Mixtec capital under Eight Deer Jaguar Claw, maintaining its independence despite coming under attack from the Aztecs between 1483–1519.

When the conquistador Pedro de Alvarado arrived March 3, 1522, he defeated Tututepec's warriors, who fought under Cuaxintecutli (Venerable Lord Serpent).

The municipality includes the large Lagunas de Chacahua National Park and the archaeological site of Villa Segura Tututepec.

[1][dubious – discuss][other ref failed verification] 90% of the population is engaged in cultivation of fruits such as watermelon, cantaloupe, papaya, hibiscus, and banana.

A caravan of bicyclists and other guests of honor inaugurated the opening of an exposition of artisan handicrafts and local cuisine, along with a book fair.