[10] Along with Vladimir Putin in 1994, who at the time headed the city mayor's committee for external relations, he helped organize the 1994 Goodwill Games which was the first major sporting event in Russia since the dissolution of the Soviet Union.

Although government officials aren't allowed to hold top positions in sports organizations, an exception was made for Mutko in July 2015.

[23] He was barred from standing in re-election as a member of FIFA Council in March 2017 due to his ministerial role that was against the statutes of political neutrality and the prevention of any form of government interference.

[24] He announced temporarily relinquishing his position on 25 December 2017 as President of Russian Football Union for a period of six months to appeal against his Olympic ban,[25] which was later lifted[26] by the Court of Arbitration for Sports in Lausanne, Switzerland.

On 18 May 2018, he was re-appointed Deputy Prime Minister, while instead of sports issues, in the new cabinet, Mutko began to oversee the construction and development of regions.

[28] On 15 January 2020, he resigned as part of the cabinet, after President Vladimir Putin delivered the Presidential Address to the Federal Assembly, in which he proposed several amendments to the constitution.

[30] On 29 January, Mutko was appointed as the chief executive officer of DOM.RF [ru], a state-owned company involved in the mortgage and realty market.

"[33] On 9 November 2015, a report by an independent commission of the World Anti-Doping Agency accused Mutko of overseeing a wide-ranging, doping scheme within Russian track and field.

[39][40] In December 2010, when Mutko was at a meeting in Zürich with the executive committee of FIFA about the 2018 World Cup's host country, he delivered a welcoming speech in English with a strong Russian accent.

This speech became well known as "Лет ми спик фром май харт" (Let me speak from my heart) and gained massive popularity on the internet.

[44] Vitaly Mutko is engaged in commercial activities in sectors of the economy that provide a significant source of income for the Russian government, which initiated military operations and genocide of civilians in Ukraine.