Vito Cruz, together with Buendia, was opened on November 24, 1975, as part of the 83rd anniversary of the Philippine National Railways.

On March 28, 2024, station operations were temporarily suspended to make way for the construction of the North–South Commuter Railway.

Further away from the station are educational institutions such as the main campus of Arellano University School of Law, the De La Salle University, the De La Salle–College of Saint Benilde and St. Scholastica's College, the Manila South Cemetery.

Vito Cruz station is accessible by jeepneys plying the Zobel Roxas Street route, as well as buses on the Osmeña Highway.

A tricycle terminal plying barangay San Antonio in Makati is located across the station on Zobel Roxas Street, while tricycles based in Manila and barangay Palanan, Makati also drop commuters off at the station.