WNNE primarily served the southern and eastern portions of the Plattsburgh–Burlington market including Sullivan and Grafton counties in west-central New Hampshire.

Additional viewership came from surrounding counties in the southern New Hampshire sub-market which is actually part of the Greater Boston designated market area.

As a result, WNNE was within reach of the home territories of sister stations WMUR-TV in Manchester, New Hampshire, and WMTW in Portland, Maine, as well as Hearst's New England flagship, WCVB-TV in Boston.

The analog channel 31 allocation in the Upper Valley was first occupied by WRLH in West Lebanon, New Hampshire, an NBC affiliate which operated from 1966 to 1968 and from 1971 to 1974.

Initially, this new television station was assigned the call letters WMVW but went on-the-air September 27, 1978, as WNNE from its facility in White River Junction.

On July 20, 2005, WNNE began broadcasting a standard definition digital signal on UHF channel 25 from a transmitter on WVTA's nearby tower on Mount Ascutney.

On November 19, 2019, WNNE, WPTZ and CBS affiliate WCAX-TV (channel 3) were knocked off the air by a fire of their combined antenna at their transmitter facility.

The outage affected over-the-air and satellite viewers; cable subscribers continued to receive the three stations via direct fiber feeds.

The original anchor team consisted of Mike Harding with news, John Yacavone providing weather, and sports from Rick Karle.

During the week, the station offered local news and weather updates from 7 to 9 a.m. at 25 and 55 minutes past the hour during Today on weekday mornings in lieu of a traditional broadcast.

Due to WNNE's central location, it was considered a perfect fit and a new satellite vehicle partially funded by the network was stationed at the outlet's White River Junction studios.

The station also maintained its own satellite truck that assisted in local news gathering efforts in the Upper Valley and the surrounding areas.

[25][26] After dropping full separate local broadcasts on weeknights, the station began inserting updates originating from its White River Junction studios during the WPTZ newscast simulcasts.

Contributions by WNNE to WPTZ's newscasts included video footage and a live headline (weeknights at 5:30) from its White River Junction studios (which was staffed with a full-time multimedia journalist).

That station was one of six remaining outlets owned by Hearst that had yet to make the upgrade to local news in enhanced definition or full HD-level.

In August 2018, WPTZ's Upper Valley bureau moved from White River Junction to a new space on Mechanic Street in Lebanon, New Hampshire.