WUPL (channel 54) is a television station licensed to Slidell, Louisiana, United States, serving the New Orleans area as an affiliate of MyNetworkTV.

The two stations share studios on Rampart Street in the historic French Quarter district; WUPL's transmitter is located on Cooper Road in Terrytown, Louisiana.

Prior to the station's sign-on, WHNO (channel 20) was approached by UPN for an affiliation, though WHNO's owner LeSEA Broadcasting declined all netlet offers on their stations through the country, as the programming planned for both UPN and competitor The WB conflicted with the company's core programming values; as a result, programming from UPN, which launched on January 16, 1995, was only available on New Orleans-area cable and satellite providers through New York City-based national superstation WWOR for the 5+1⁄2 months prior to WUPL's debut.

On January 24, 2006, Time Warner and CBS Corporation (the latter of which took over WUPL and UPN after Viacom split into two companies one month earlier) announced that both companies would partner to launch The CW, which would replace The WB and UPN; the network, which debuted on September 18, 2006, would feature a mix of programs carried over from its two predecessor networks as well as newer series.

The deal was slated to close by the end of 2005, but was placed on hold when Hurricane Katrina devastated the New Orleans metropolitan area in late August of that year.

[7] At that time, Belo closed on WUPL, and later acquired its low-power repeater, WBXN-CA (channel 18; previously a separate station, K10NG, affiliated with The Box and later MTV2) on April 20, 2007.

Occasionally as time permits, WUPL may air CBS network programs whenever WWL-TV is unable to in the event of extended breaking news or severe weather coverage.

The WWL-produced 9 p.m. newscast ended its run on WUPL after the April 26, 2013, edition, having been canceled due to consistently low ratings; three days later on April 29, the program was replaced by The 504, a pre-recorded interview show originally hosted by WWL-TV weekday morning co-anchor Melanie Herbert; it was hosted by Sheba Turk, who was a WWL morning anchor until relocating to KCBS-TV/KCAL-TV in 2023.

When MundoMax went dark on November 30, 2016, WUPL duplicated its main feed on its second subchannel until the addition of the newly-launched Quest network in late January 2018.