Wallace County is home to Mount Sunflower, the highest point in Kansas at 4,039 feet (1,231 meters).

For many millennia, the Great Plains of North America was inhabited by nomadic Native Americans.

In 1802, Spain returned most of the land to France, but keeping title to about 7,500 square miles.

In 1803, most of the land for modern day Kansas was acquired by the United States from France as part of the 828,000 square mile Louisiana Purchase for 2.83 cents per acre.

Only two Democratic presidential nominees have ever won Wallace County – Woodrow Wilson in 1916 and Franklin D. Roosevelt in 1932.

Since 1944 only three Democratic presidential candidates have won 31 percent of Wallace County's vote – Harry S. Truman in 1948, Lyndon Johnson in 1964 and Jimmy Carter in 1976 – whilst since 1980 only Michael Dukakis during the drought-affected 1988 election has obtained so much as seventeen percent for the Democratic Party.

In the 2012, 2016, 2020, and 2024 elections, Wallace was the only county in Kansas to give over 90% of the vote to the Republican nominee, namely Mitt Romney followed by Donald Trump.

[12] † means a community is designated a Census-Designated Place (CDP) by the United States Census Bureau.