Wayne Lee Twitchell (March 10, 1948 – September 16, 2010) was an American Major League Baseball right-handed pitcher.

Twitchell played basketball, football and baseball at Wilson High School in Portland, Oregon.

He went 21–26 with a 3.53 earned run average and 402 strikeouts mostly as a starting pitcher over four seasons in the Astros' farm system.

After the 1969 season, in one of their last transactions before relocating and becoming the Milwaukee Brewers, the Seattle Pilots purchased Twitchell.

[2] During Spring training 1971, he was traded to the Philadelphia Phillies for minor league outfielder Pat Skrable.

Twitchell spent the 1971 season in triple A, and again received a call up to the majors when rosters expanded in September.

His season debut was a start against the New York Mets, in which he allowed three unearned runs in four innings.

The Phillies began the 1972 season with Dick Selma in the starting rotation and Twitchell in the bullpen.

[8] New Phillies manager Danny Ozark moved Twitchell back into the bullpen for the 1973 season.

After posting a 1.98 ERA in six relief appearances, Twitchell was moved back into the starting rotation.

He pitched the sixth inning, and gave up a double to the first batter he faced (Kansas City's John Mayberry).

He then struck out Reggie Jackson and retired the next two batters to escape the inning without giving up a run.

Facing the Cubs again on September 18, he collided with Billy Williams while covering first base on a ground ball.

He pitched better in May (2.81 ERA), but by then the decision had been made to give top prospect and former first round pick Larry Christenson Twitchell's rotation spot.

After a final start against the Mets on July 6,[17] Twitchell was moved into the bullpen, and assigned to "mop up duty."

Cincinnati's "Big Red Machine" made short work of them in the 1976 National League Championship Series, sweeping them in three games.

[22] Two days later, he and catcher Tim Blackwell were traded to the Expos for Barry Foote and Dan Warthen.

After Rusty Staub led the inning off with a home run, Twitchell walked the bases loaded.