Published by Bill Gaines and edited by Al Feldstein, the bi-monthly Weird Science replaced Saddle Romances with the May/June 1950 issue.

[1] Although the title and format change took effect with issue 12, Gaines and Feldstein decided not to restart the numbering in order to save money on second class postage.

Artist/Writer Harry Harrison claims credit for originally giving Gaines the notion of publishing science fiction.

[3] Harrison, however, had no editorial control over the contents of the comic aside from his own stories and left EC by the end of 1950.

The other Weird Science interior artists were Feldstein, Frank Frazetta, Al Williamson, Joe Orlando, George Evans, Harvey Kurtzman, George Roussos, Harrison, Will Elder, Jack Kamen, Sid Check and Jack Olesen.

Writers in the early issues included Feldstein, Gaines, Kurtzman, Harrison and Gardner Fox.

[4] As with other EC Comics, Gaines and Feldstein used some Weird Science stories to teach moral lessons.

In 2007, Cochran and Gemstone began to publish hardcover, re-colored volumes of Weird Science as part of the EC Archives series.

It has been suggested on The Simpsons season 3 DVD commentary for the episode "Treehouse of Horror II" that the appearance of Kang and Kodos was based on cover art from EC Comics.

No specific issue number is mentioned, but it may be a combination of different covers including possibly Weird Science #6 and #16.