Welgemoed lies in the northern reaches of Bellville on the slopes of the Tygerberg Hill at an altitude of 310 m (1017 ft), making it the highest suburb of the city.

As a result of its location, the suburb offers views overlooking Bellville and the Greater Cape Town metropolitan area.

Welgemoed can be also be used as a collective for its neighbouring suburbs stretching from Loevenstein to Kanonberg and includes the suburbs of Welgemoed Greens, De Bron, Protea Valley, Door de Kraal, Van Riebeeckshof, Oude Westhof, Welgedacht, Hoheizen, Blomvlei and Selborne.

[7] Jip de Jäger Avenue (M16) is the suburb's main road, connecting to the N1 highway and Bellville West in the south and Durbanville in the north-east.

In the broader area of Welgemoed, Van Riebeeckshof Road connects the suburbs of Van Riebeeckshof, Protea Valley, Door de Kraal, Oude Westhof, Kanonberg and Welgedacht, which lie north of Welgemoed with Kenridge to the east.