The Welsh Marches line (Welsh: Llinell y Mers), known historically as the North and West Route, is a railway line running from Newport in south-east Wales to Shrewsbury in the West Midlands region of England.

It follows a route by way of Abergavenny, Hereford and Craven Arms and thence, by some definitions, to Crewe via Whitchurch.

The line thus links the south of Wales to north-west England, via the Welsh Marches region, bypassing Birmingham.

Under the 1960s Beeching Axe, many of the supporting branch lines and the Hereford Barton loop were closed.

The cities, towns and villages served by the routes are listed below from south to north: Transport for Wales operates all passenger services on the line, on the following routes:[3] While Great Western Railway does not operate any passenger services along the line, the operator moves its Class 800 empty rolling stock at 05:50 and 06:33 in the morning, and 22:10 and 23:38 at night along the Hereford to Newport section of the line, where stock returns to Stoke Gifford depot, near Filton.