The natural region is located in the central part of the North German Plain, straddling the border between the states of Lower Saxony (only the county of Lüchow-Dannenberg) and Saxony-Anhalt (counties of Altmarkkreis Salzwedel, Stendal and Börde).
It extends from Dannenberg in the north via Lüchow and Salzwedel to the Breslau-Magdeburg-Bremen glacial meltwater valley (including the River Ohre and Mittelland Canal) north of Magdeburg in the south; and from the Lower Saxony / Saxony-Anhalt border region northeast of Wolfsburg and the Drömling in the west as far as Stendal in the east.
For example, the Drawehn region is socio-culturally mainly part of the Hanoverian Wendland, but is party of the Lüneburg Heath landscape unit, D28.
The flood plain of the Elbe also forms a separate natural region.
The major landscape group of Wendland and Altmark (86) is bounded and bordered by the groups of Lüneburg Heath (64) to the northwest, the Weser-Aller Plain (62) to the southwest, the Eastern Harz Foreland and Börde (50) to the south and the Elbe Valley (87) to the east and north.