Wesley was founded by the Congregational Methodist Church and served as that denomination's sole institution of higher education.

The center of the campus was marked by a quadrangle featuring a large gazebo where students were routinely seen studying or lounging.

The school fielded a men's basketball team and a women's volleyball team in the National Christian College Athletic Association (NCCAA)'s Division II South Region where they took a national title in 1990 and were ranked number 1 going into the 2006–2007 season.

Wesley College was established and operated as an instrument to equip ministers, missionaries, and lay leaders for Christian service.

Her students have gone forth to successful lives and careers, building on foundations established at Wesley College.