It is mainly located on Seram, but includes various islands lying to the west of Seram - the largest being Manipa, Kelang and Boano, as well as the smaller islets of Babi, Pua, Masowoi, and Marsegu.

[1] The principal town lies at Piru, a port at the northern coast of Latira Bay (Teluk Latira) which is a northwards extension of Piru Bay (Teluk Piru) and almost separates the Huamual Peninsula from the rest of Seram Island.

The western sector of the Regency (the Huamual Peninsula and the islands off the west coast) occupies just under 25% of the land area, but held over 42% of the Regency's population at the 2020 Census.

The district comprises 5 towns and villages (all desa) - Lohu (with 26,184 inhabitants in mid 2022), Lokki (12,568), Iha (6,210), Ariate (1,182) and Kulur (918).

(d) the 7 desa are Piru (a town with 16,368 inhabitants in mid 2022), Kaibobo, Eti, Lumoli, Morekau, Neniari and Kawa.