In the south, Weston Road begins at St. Clair Avenue opposite the north end of the southern leg of Keele Street.

The southernmost 55 metres of the street north of St. Clair, where the roadway diverted to the west off its straight baseline, was formerly a part of Keele, which officially breaks here and is cut off from its short mid-section.

North of St. Phillips, it becomes a north-south artery but does not align to the grid proper until south of Sheppard Avenue.

It begins as a minor stub running north from intersection of Dundas, Dupont and Annette Streets, and breaks at the Canadian Pacific tracks, which were bridged until the 1970s.

[citation needed] The second is located in Vaughan, just north of Steeles Avenue, and was created when a jog was eliminated in the 1990s.

It lies just east of the linking segment where it continues south as Signet Drive (built as a southerly extension of the offset York Region section), and ends at a T-intersection with Weston Road two blocks north of Steeles.

York Region Transit route 165 Weston serves Weston Road north of Steeles Avenue, running from Pioneer Village station to the Major Mackenzie West Terminal, which is located to the north of Canada's Wonderland.