Wickliffe is a census-designated place (CDP) in Mayes County, Oklahoma, United States.

[4] According to the United States Census Bureau, the CDP has a total area of 1.2 square miles (3.1 km2), all land.

The racial makeup of the CDP was 49.49% White, 41.41% Native American, 1.01% Asian, and 8.08% from two or more races.

14.7% of all households were made up of individuals, and 8.8% had someone living alone who was 65 years of age or older.

There were 19.5% of families and 12.8% of the population living below the poverty line, including 17.0% of under eighteens and none of those over 64.