The G&SIRR was completed between Gulfport and Hattiesburg on January 1, 1897, and the town of Wiggins was the busiest population center along that route.

[9] By the end of the 20th century, the Wiggins depot had fallen into a state of disrepair and was being used only for storage and as periodic office space by railroad personnel.

[13] On December 6, 2000, the depot was moved approximately 3 blocks to its new location on City property that was acquired in a land swap with Stone County.

[15] During the summer of 2005, restoration of the depot was completed under the direction of architect Kevin Fitzpatrick, and Stone County Economic Development Partnership (SCEDP) occupied the building in mid-August of that year.

[19] The tornado damage was repaired using funds obtained through an insurance settlement, and SCEDP moved back into the depot in June 2009.