Former Louisville & Nashville services which utilized their station included the Gulf Wind (New Orleans–Jacksonville), Pan-American (New Orleans–Cincinnati) and Humming Bird (New Orleans–Cincinnati), as well as an additional unnamed day train (New Orleans–Jacksonville).

[3] Amtrak service began with the Gulf Coast Limited, which operated between 1984 and 1985 and called at the station.

It is also a contributing property of the Gulfport Harbor Square Commercial Historic District.

[8] Train service has been suspended since Hurricane Katrina struck Gulfport in 2005.

[9][1] In anticipation of a new service between New Orleans and Mobile, Amtrak installed new station signs in 2023.