He also voiced Ron Stoppable in Kim Possible (2002–2007), Doyle Blackwell in The Secret Saturdays (2008), Jaime Reyes / Blue Beetle in Batman: The Brave and the Bold (2008–2011), Lion-O in the 2011–12 reboot of ThunderCats, Bumblebee in the Transformers franchise (2013–2016), Star-Lord in Guardians of the Galaxy (2015–2019), and Kashaw Vesh in The Legend of Vox Machina (2022).

He stated that he learned he was being inaccurately credited by Occidental College as being an alumnus when his nephew visited the school and showed him the information package.

for three seasons (1988–1991), Friedle's breakthrough came when he was cast as Cory Matthews's likeable but underachieving elder brother Eric on the long-running TV sitcom Boy Meets World from 1993 to 2000.

[6][7][8] In 1998, he starred with Elisabeth Harnois, Dabney Coleman, and Jay Thomas in My Date with the President's Daughter as part of The Wonderful World of Disney.

[9] In December 2013, in spite of initial reluctance, it was announced that Friedle would reprise his role as Eric in the sequel series Girl Meets World.

[15][17] In 2013, Entertainment Weekly commented that "Friedle has largely ditched on-camera acting for voiceover work", though he is "nevertheless best known as Eric Matthews, Cory's cute but dim brother on Boy Meets World".

[29][30] After the conclusion of that series, Ray reached out to pitch Mini Primetime (2019) where Friedle would host a similar painting show for Critical Role's new YouTube channel.

In June 2022, the podcast did a Kim Possible 20th anniversary special episode with creators Mark McCorkle and Bob Schooley and voice actors John DiMaggio (Drakken) and Nicole Sullivan (Shego), as well as a brand new Kim Possible scene with the four actors written by McCorkle and Schooley and directed by original voice director Lisa Schaffer.

[35] In 2024, he began to co-host the rewatch podcast Magical Rewind with Sabrina Bryan, which focuses on Disney Channel Original Movies.