Wood's piano-led style often changes from one song to the next, drawing influence from folk, pop, jazz, rock and roll, latin music, doo wop, and klezmer.

When recording in studio or performing live with his band, the Tapeworms, he has mostly been accompanied by Mike Bottiglieri on guitar, Matt Berger on alto saxophone, Mario Conte on drums, Vater Boris on bass, and Rob Schaefer on trumpet.

His acts sometimes feature simulated mental breakdowns, conflict with audience plants, appearances from fictional characters, and intentionally botched performances.

[11] Wood has consistently been open about his past struggles with drug addiction and mental illness, having entered recovery early in his career and later being diagnosed with bipolar disorder.

"[14] Wood began releasing music with A Verbal Equinox and Strange Thick[15] on January 19, 2011, before later joining Jamface[16] in summer of the same year to replace the female lead vocalist under the pseudonym "William Sunshine."

[23] Other singles included "Tomcat Disposables", "Cicada Days", "Euthanasia", and "White Noise", all of which were accompanied by music videos co-created by Wood.

[24][25] On August 19, 2022, Wood was featured on singer-songwriter Shayfer James' single "Ferryman",[26] which would later appear on the latter's third studio album Shipwreck (2023).

[28] On January 13, 2023, Wood released the album IN CASE I DIE:, a live compilation of songs recorded at US tour dates in 2022.

"[29] On August 9, 2024, Will Wood released a new mix of The Normal Album (2020) with producer Kevin Antreassian, additionally featuring three demos.