The district headquarters at Kasese are located approximately 359 kilometres (223 mi), by road, west of Kampala, Uganda's capital and largest city.

However, there are other ethnic groups in the district who include the Banyankole, the Basongora the Bakiga and the Baganda.

Kasese district is mainly agricultural with over 85 percent of the people being peasant farmers who depend on subsistence farming for their livelihood.

Crops grown include: Most of the agricultural produce is either sold locally or transported for sale in Kampala and to other cities and towns in Uganda.

There are two main landing sites on the shores of Lake George, Mahyoro and Kayinja.